Promotes Mental Clarity & Relaxation‡

Calm

Capsule · 90 capsules · 90 servings · $75 · $0.83/serving

Relaxation, not sedation.‡ Calm is designed to help quiet the noise while supporting a clear, steady state — morning, afternoon, or before bed.‡

Featuring L-theanine, phosphatidylserine, saffron, rhodiola, vitamin C, and zinc. Calm supports relaxation, mental clarity, mood, and a healthy stress response without slowing you down.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational support, morning or night.

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Formulation

  • From Sunflower Lecithin.
  • Rhodiola Rosea (root). Standardized to 3% Rosavins, 1% Salidrosides.
  • Crocus Sativus (flower). Standardized to 7% Crocins, 1% Safranals.
  • As Ascorbic Acid.
  • As Zinc Bisglycinate.

How to Take

Take one (1) capsule daily, or as recommended by your healthcare professional.

The Science

Calm was designed around nutrients and botanicals that support relaxed alertness, mental clarity, mood, and a healthy stress response.‡ L-theanine supports a calm, focused state; phosphatidylserine supports healthy stress physiology; saffron supports mood and emotional well-being; and rhodiola supports resilience during periods of stress and fatigue.‡

  1. L-theanine and relaxed attention — Human study evaluating L-theanine's effects on attention and reaction time response in healthy volunteers. DOI: 10.1016/j.jff.2011.03.009
  2. L-theanine and perceived stress — Human study evaluating daily L-theanine supplementation and perceived stress in healthy adults. PMCID: PMC11263523
  3. Phosphatidylserine and the stress response — Human study evaluating phosphatidylserine supplementation and endocrine response to exercise-induced stress. PMID: 18662395
  4. Saffron and emotional well-being — Human study evaluating standardized saffron extract supplementation and mood, well-being, and stress-related outcomes in healthy adults. PMID: 33598475
  5. Rhodiola and stress resilience — Review of clinical evidence evaluating Rhodiola rosea preparations in stress, fatigue, and mental performance contexts. PMID: 35745023

Supports Bone Density & Cardiovascular Health‡

Daily D3/K2

Capsule · 90 capsules · 90 servings · $50 · $0.56/serving

A research-supported D3 dose (5,000 IU), with dual-form K2 to direct calcium where it belongs.‡ Includes Boron and Magnesium Taurate to support vitamin D activation.‡

Vitamin D3 supports calcium absorption and healthy vitamin D levels, while vitamin K2 supports vitamin K-dependent proteins involved in bone and vascular health.‡ Magnesium and boron provide additional mineral cofactors that support vitamin D metabolism and healthy calcium balance.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational support.

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Formulation

  • As Cholecalciferol.
  • As Menaquinone-4. Fast-acting form, active in bone and brain tissue.
  • As Menaquinone-7. ~72-hour half-life for sustained calcium management.‡
  • As Magnesium Taurate. Required to convert vitamin D into its active form.
  • As Boron Glycinate. Supports vitamin D utilization.‡

How to Take

Take one (1) capsule daily with breakfast, or as recommended by your healthcare professional.

The Science

Daily D3/K2 was designed to support healthy vitamin D status, calcium metabolism, bone health, and cardiovascular health through complementary nutrient pathways.‡ Vitamin D3 supports calcium absorption, vitamin K2 supports vitamin K-dependent proteins involved in calcium utilization, and magnesium and boron support additional steps in vitamin D activation and mineral homeostasis.‡

  1. MK-4 and calcium homeostasis in cardiovascular health — Review discussing MK-4 and its role in calcium homeostasis in cardiovascular health. PMID: 34785587
  2. MK-7 and bone quality — Review discussing MK-7 bioavailability, vitamin K-dependent proteins, and bone quality and strength pathways. PMID: 32244313
  3. Magnesium and vitamin D activation — Review discussing magnesium's role in vitamin D activation, calcium regulation, and bone-related physiology. PMID: 29480918
  4. Boron and vitamin D function — Review discussing boron's role in mineral metabolism and vitamin D-related physiology. PMID: 26770156

Neuroendocrine Support‡

P5P+

Capsule · 90 capsules · 90 servings · $70 · $0.78/serving

A multi-pathway formula designed to support healthy neuroendocrine function, neurotransmitter production, cognitive performance, and a healthy stress response.‡

Featuring active vitamin B6 as P5P, rhodiola, ginkgo, L-tyrosine, apigenin, and triacetyluridine, P5P+ combines cofactors, adaptogens, botanical extracts, and nutrient precursors that support mental clarity, stress resilience, and healthy neurotransmitter pathways.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational neuroendocrine support.

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Formulation

  • As Pyridoxal-5-Phosphate (P5P) — the active coenzyme form.
  • Rhodiola Rosea (root).
  • Ginkgo Biloba (leaf). Standardized to 24% Ginkgo Flavone Glycosides.
  • As Triacetyluridine.

How to Take

Take one (1) capsule daily with food, or as recommended by your healthcare professional.

The Science

P5P+ was designed around nutrients and botanicals that support neurotransmitter synthesis, cognitive function, mental performance, and a healthy stress response.‡ P5P is the active coenzyme form of vitamin B6 and supports enzyme pathways involved in neurotransmitter production, while rhodiola, ginkgo, L-tyrosine, apigenin, and triacetyluridine support complementary neuroendocrine and cognitive pathways.‡

  1. P5P and neurotransmitter synthesis — Review discussing pyridoxal-5-phosphate as a coenzyme in amino acid decarboxylation reactions involved in neurotransmitter synthesis. PMID: 30037155
  2. L-tyrosine and cognitive performance under stress — Controlled study evaluating L-tyrosine supplementation and cognitive task performance under acute stress conditions. PMID: 8293316
  3. Rhodiola and stress resilience — Review of clinical evidence evaluating Rhodiola rosea preparations in stress, fatigue, and mental performance contexts. PMID: 35745023
  4. Ginkgo and cognitive support — Review evaluating Ginkgo biloba for cognitive improvement in healthy individuals. PMCID: PMC6513461
  5. Apigenin and neurotransmitter receptor pathways — Study evaluating apigenin's interaction with GABAergic and glutamatergic receptor signaling pathways. PMID: 15464088
  6. Uridine and synaptic membrane support — Study discussing uridine as a circulating precursor involved in synaptic membrane phosphatide pathways. PMID: 19262950

Supports Healthy Thyroid Function‡

Thyroid Support

Capsule · 90 capsules · 90 servings · $75 · $0.83/serving

A comprehensive thyroid support formula designed to provide key nutrient cofactors involved in healthy thyroid hormone production, thyroid hormone conversion, antioxidant protection, and metabolic function.‡

Featuring iodine, selenium, zinc, vitamin A, active B vitamins, black cumin extract, forskolin, myo-inositol, taurine, and L-tyrosine, Thyroid Support helps support the nutritional pathways your thyroid relies on every day.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational thyroid support.

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Formulation

  • As Retinyl Palmitate.
  • As Riboflavin-5-Phosphate (R5P) — the active form.
  • As Pyridoxal-5-Phosphate (P5P).
  • As Potassium Iodide. Structural backbone of thyroid hormones.
  • As Zinc Bisglycinate.
  • As L-Selenomethionine. Supports thyroid hormone conversion.‡
  • As Copper Bisglycinate.
  • As Chromium Picolinate.
  • Nigella Sativa (seed). 10:1 extract — equivalent to 1,000 mg of seed oil.
  • From Coleus Forskohlii (root) extract.
  • Provides the amino acid backbone of T3 and T4.

How to Take

Take one (1) capsule daily with breakfast, or as recommended by your healthcare professional.

The Science

Thyroid Support was designed around nutrients and botanicals involved in healthy thyroid hormone production, conversion, and antioxidant defense.‡ Iodine and tyrosine are structural components of thyroid hormones; selenium supports deiodinase enzymes involved in thyroid hormone activation; and zinc, riboflavin, and P5P support broader thyroid-related metabolic pathways.‡

  1. Selenium in thyroid hormone metabolism — Review discussing selenium's role in thyroid hormone metabolism, deiodinase activity, and thyroid antioxidant defense systems. PMID: 28255299
  2. Zinc and thyroid-related metabolism — Review discussing trace elements, including zinc and selenium, in thyroid hormone metabolism and thyroid-related physiology. PMCID: PMC7282437
  3. Black cumin and thyroid wellness — Human study evaluating Nigella sativa and thyroid-related markers. PMID: 27852303
  4. Myo-inositol and thyroid-related signaling — Review discussing myo-inositol's role in thyroid physiology and thyroid-related signaling pathways. PMCID: PMC8143049

Supports Healthy Liver Function‡

Liver Support

Capsule · 180 capsules · 90 servings · $125 · $1.39/serving

A targeted liver support formula featuring a full-strength 500mg serving of TUDCA, plus CDP-choline, glycine, and myo-inositol to support liver cell health, bile acid metabolism, glutathione production, and hepatic fat metabolism.‡

TUDCA supports liver cell health and healthy bile acid metabolism, while CDP-choline supports cell membrane integrity and normal hepatic fat metabolism.‡ Glycine provides amino acid support for glutathione production, and myo-inositol supports metabolic signaling pathways relevant to healthy liver function.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational liver support.

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Formulation

  • Tauroursodeoxycholic Acid. Supports liver cell health and the body's response to cellular stress.‡
  • Citicoline. Essential for healthy hepatic fat metabolism.‡
  • The rate-limiting precursor for glutathione.

How to Take

Take two (2) capsules daily with food, or as recommended by your healthcare professional.

The Science

Liver Support was designed around complementary nutrients that support liver cell health, bile acid metabolism, cell membrane integrity, glutathione production, and hepatic fat metabolism.‡ TUDCA provides bile acid support, CDP-choline provides choline for liver and membrane-related pathways, glycine supports glutathione production, and myo-inositol supports metabolic signaling pathways relevant to healthy liver function.‡

  1. TUDCA and liver cell health — Review discussing TUDCA's molecular and cellular effects, including hepatobiliary and cellular stress-response pathways. PMCID: PMC6952947
  2. Bile acids and liver physiology — Review discussing bile acids as physiological molecules involved in bile flow, nutrient absorption, lipid transport, and liver metabolic signaling. PMID: 19346330
  3. Choline and liver function — Review discussing choline's role in maintaining liver function and supporting hepatic lipid transport pathways. PMID: 23493015
  4. Glycine and glutathione synthesis — Review discussing glycine's role as a substrate for glutathione synthesis and antioxidant support. PMID: 29559876
  5. Inositol and liver metabolic health — Review discussing inositol pathways relevant to liver lipid metabolism and metabolic liver health. PMCID: PMC7694137

Promotes Healthy Glucose Metabolism‡

Berberine⁵

Capsule · 180 capsules · 90 servings · $75 · $0.83/serving

Built around GlucoVantage® Dihydroberberine — a reduced berberine derivative formulated for enhanced berberine bioavailability and improved GI tolerability. Enhanced with myo-inositol, thiamine, and chromium picolinate for comprehensive glucose and metabolic support.‡

Berberine⁵ is designed to support healthy glucose metabolism, metabolic signaling, nutrient cofactor pathways, and cellular energy metabolism.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational metabolic support.

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Formulation

  • As GlucoVantage® — the active metabolite of berberine, up to 5x greater bioavailability.
  • As Thiamine HCl. Cofactor support.
  • As Chromium Picolinate. Supports glucose metabolism cofactor activity.‡
  • Supports metabolic signaling.‡

How to Take

Take one (1) capsule with food up to twice daily, or as recommended by your healthcare professional.

The Science

Berberine⁵ was designed around nutrients that support healthy glucose metabolism, metabolic signaling, and nutrient cofactor pathways.‡ GlucoVantage® Dihydroberberine provides a bioavailable berberine derivative, while myo-inositol supports glucose metabolism signaling pathways, chromium supports normal macronutrient metabolism, and thiamine supports cellular energy metabolism.‡

  1. Berberine and glucose metabolism — Systematic review and meta-analysis evaluating berberine's effects on glucose-lipid metabolism and metabolic health. PMCID: PMC12307485
  2. Myo-inositol and insulin signaling — Review discussing inositols in insulin signaling, glucose metabolism, and metabolic physiology. PMCID: PMC6286734
  3. Chromium and glucose metabolism — Systematic review discussing chromium supplementation and glucose-related metabolic outcomes. PMID: 24635480

Supports Healthy Homocysteine Metabolism‡

Methylate

Capsule · 180 capsules · 90 servings · $70 · $0.78/serving

Precision methylation support for healthy homocysteine levels, with triple-form B12, TMG, CDP-Choline, & L-MethylFolate — not a generic B-complex.‡

Methylate is designed to support methylation pathways, healthy homocysteine metabolism, cellular energy metabolism, and healthy B12 status.‡ TMG and CDP-choline provide methyl donor support through complementary pathways, while L-5-MTHF, B12, riboflavin, and P5P support folate- and B-vitamin-dependent methylation pathways.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational methylation support.

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Formulation

  • As L-5-MTHF — the active, bioavailable methyl form.
  • Triple-form: 600mcg Methylcobalamin, 600mcg Hydroxocobalamin, 600mcg Adenosylcobalamin — supports methylation pathways across varied biochemistries.‡
  • As R5P — the active coenzyme form. Supports healthy methylation pathways.‡
  • As P5P — the active coenzyme form.
  • As Zinc Bisglycinate.
  • As Betaine Anhydrous. Provides methyl donors through the BHMT pathway.
  • Citicoline. Methyl donor through the complementary BHMT pathway.

How to Take

Take two (2) capsules daily, or as recommended by your healthcare professional.

The Science

Methylate was designed around nutrients involved in one-carbon metabolism, methylation pathways, and healthy homocysteine metabolism.‡ L-5-MTHF and B12 support the folate cycle and methionine synthase reaction, TMG and CDP-choline support methyl donor availability through complementary pathways, and riboflavin and P5P support broader B-vitamin-dependent methylation reactions.‡

  1. Betaine and methyl donor support — Review discussing betaine as a methyl donor involved in homocysteine remethylation through betaine-homocysteine methyltransferase pathways. PMCID: PMC8224793
  2. Choline, betaine, and homocysteine metabolism — Review discussing choline conversion to betaine and its role as a substrate in the betaine-homocysteine methyltransferase reaction. PMID: 20446114
  3. Riboflavin and MTHFR-related methylation pathways — Human study evaluating riboflavin's role in homocysteine metabolism in individuals with the MTHFR 677TT genotype. PMID: 16380544

Supports Healthy Neuromuscular Function‡

Mag2+ Boron

Capsule · 360 capsules · 90 servings · $70 · $0.78/serving

A bedtime mineral stack featuring magnesium bisglycinate and boron to support healthy neuromuscular function, relaxation, sleep quality, recovery, bone mineral metabolism, and hormone-related pathways.‡

Both the magnesium and boron are bound to glycine, a naturally calming amino acid involved in relaxation and healthy sleep physiology.‡ This highly tolerable form was selected for consistent daily use, especially as part of an evening mineral routine.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational mineral support.

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Formulation

  • From 2,222mg Magnesium Bisglycinate. Highly bioavailable chelated form; gentle on digestion.
  • Boron Bisglycinate. Supports healthy free testosterone levels.‡

How to Take

Take four (4) capsules daily at bedtime, or as recommended by your healthcare professional.

The Science

Mag² + Boron was designed around two complementary minerals that support neuromuscular function, relaxation, sleep physiology, mineral metabolism, and healthy hormone-related pathways.‡ Magnesium supports normal muscle and nerve function and plays a role in vitamin D activation, while boron supports mineral metabolism, vitamin D-related physiology, and healthy free testosterone pathways.‡

  1. Magnesium and neuromuscular function — Reference review discussing magnesium's role in normal muscle and nerve function, energy metabolism, and physiological mineral balance. NIH ODS: Magnesium
  2. Magnesium and sleep physiology — Systematic review evaluating magnesium status, magnesium intake, and sleep-related outcomes in adults; observational evidence suggested associations, while randomized trial evidence was mixed. PMID: 35184264
  3. Magnesium and vitamin D activation — Review discussing magnesium's role in vitamin D activation, calcium regulation, and bone-related physiology. PMID: 29480918
  4. Boron and vitamin D function — Review discussing boron's role in mineral metabolism and vitamin D-related physiology and bone health pathways. PMID: 26770156
  5. Boron and healthy free testosterone pathways — Human study evaluating short-term boron supplementation and markers related to free testosterone, vitamin D, and inflammatory biomarkers in healthy males. PMID: 21129941

Supports Digestive & Immune Health‡

Glutamine

Powder · 90 servings · $30 · $0.33/serving

Pure L-Glutamine powder providing 5 grams per serving to support digestive health, gut lining integrity, and immune-cell energy metabolism.‡

Glutamine is a key fuel source for intestinal cells, helping support the structure and function of the gut lining.‡ A healthy gut lining supports digestive resilience and balanced immune function.‡ Immune cells also rely on glutamine for energy, especially during periods of increased metabolic demand.‡

A clean, unflavored powder tested for purity, potency, and contaminants. Built for daily foundational support.

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Formulation

How to Take

Mix 1 scoop (5g) into water once daily each morning, or as recommended by your healthcare professional.

The Science

Glutamine is the most abundant amino acid in the body and plays an important role in digestive and immune health. It serves as a key fuel source for intestinal cells and immune cells, helping support gut lining integrity, digestive function, and immune-cell energy metabolism.‡

  1. Glutamine metabolism and immune function — Reviews glutamine's role in immune-cell metabolism, intestinal function, and increased-demand states. PMID: 30360490
  2. Glutamine and intestinal barrier function — Reviews glutamine's role as a fuel source for intestinal cells and its involvement in maintaining gut barrier structure and function. PMID: 25810794
  3. Glutamine and intestinal physiology — Reviews glutamine's role in enterocyte function, tight junction regulation, and intestinal stress response pathways. PMID: 28498331
  4. Glutamine supplementation and exercise-related gut stress — Human study evaluating oral glutamine supplementation and markers of intestinal permeability after high-intensity endurance exercise. PMID: 24285149

Supports Relaxation‡

Glycine

Powder · 90 servings · $30 · $0.33/serving

Pure Glycine Powder providing 5 grams per serving to support relaxation, restful sleep, and glutathione production.‡

Glycine is a naturally sweet amino acid that helps support healthy thermoregulation, an important part of the body's natural sleep-onset process.‡ Glycine also serves as a building block for glutathione, the body's primary endogenous antioxidant.‡

A clean, unflavored powder tested for purity, potency, and contaminants. Built for daily foundational support. Naturally sweet-tasting and easy to mix into water, tea, or your preferred evening beverage.

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Formulation

How to Take

Mix 1 scoop (5g) into water or chamomile tea once daily at bedtime, or as recommended by your healthcare professional.

The Science

Research suggests glycine may support sleep quality in part by helping the body's natural thermoregulatory processes before sleep, while also serving as a building block for glutathione, the body's primary endogenous antioxidant.‡

  1. Glycine and subjective sleep quality — Human study evaluating glycine ingestion before bedtime and subjective sleep quality in volunteers with sleep concerns. DOI: 10.1111/j.1479-8425.2007.00262.x
  2. Glycine and daytime performance after restricted sleep — Human study evaluating glycine's effects on subjective sleepiness, fatigue, and performance after sleep restriction. PMID: 22529837
  3. Glycine, thermoregulation, and sleep physiology — Mechanistic study evaluating glycine's sleep-promoting and hypothermic effects through thermoregulatory pathways. PMID: 25533534
  4. Glycine and glutathione synthesis — Review discussing glycine's role as a substrate for glutathione synthesis and antioxidant support. PMID: 29559876

Supports Brain Energy‡

Creatine

Powder · 90 servings · $30 · $0.33/serving

Pure, micronized Creatine Monohydrate providing 5 grams per serving to support brain energy, muscle performance, strength, and recovery.‡

Creatine helps replenish the body's phosphocreatine reserves — a rapid energy system used by muscles and the brain during periods of high demand.‡ By supporting cellular energy availability, creatine helps fuel short, intense efforts, cognitive performance, and daily physical output.‡

A clean, unflavored powder tested for purity, potency, and contaminants. Built for daily foundational support. Micronized for superior mixability.

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Formulation

  • Micronized for superior mixability.

How to Take

Mix 1 scoop (5g) into water once daily, or as recommended by your healthcare professional.

The Science

Creatine is one of the most researched nutritional compounds in sports performance and human physiology. It supports the body's phosphocreatine system, which helps rapidly regenerate ATP — the primary energy currency used by cells during high-demand states.‡

  1. Creatine and cognitive performance in healthy individuals: systematic review of RCTs — Reviews randomized controlled trials evaluating creatine and cognitive performance in healthy people. PMID: 29704637
  2. Creatine supplementation and cognitive function: systematic review and meta-analysis — Reviews evidence on creatine's role in cognitive outcomes in adults. PMID: 39070254
  3. Creatine, cerebral energy metabolism, and sleep deprivation — Human study evaluating creatine's effects on cognitive performance and cerebral high-energy phosphates during sleep deprivation. PMID: 38418482
  4. ISSN position stand on creatine safety and efficacy — Broad evidence review supporting creatine monohydrate for exercise performance, recovery, and safety when used appropriately. PMID: 28615996