Marek Supplements Methylate — black 180-capsule bottle with methylfolate, TMG, B-vitamins, zinc, and citicoline label
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Methylate Supplement Facts panel listing methylfolate (5-MTHF), trimethylglycine, vitamin B2 (R5P), B6 (P5P), B12, zinc, and citicoline doses

Methylate

Supports Healthy Homocysteine Metabolism‡

Dietary Supplement MD Formulated 90-Day Supply

30-Day Money Back
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Product details

$0.70/day

Precision methylation support for healthy homocysteine metabolism, featuring triple-form B12, TMG, CDP-choline, L-5-MTHF, active B vitamins, and zinc — not a generic B-complex.‡

Methylate is designed to support methylation pathways, healthy homocysteine metabolism, cellular energy metabolism, and healthy B12 status.‡ TMG and CDP-choline provide methyl donor support through complementary pathways, while L-5-MTHF, B12, riboflavin, and P5P support folate- and B-vitamin-dependent methylation pathways.‡

A clean, capsule-based formula tested for purity, potency, and contaminants. Built for daily foundational methylation support.

Per Serving
  • 1200mcg DFE Folate (as L-5-MTHF)
  • 1800mcg Vitamin B12 (as 600mcg Methylcobalamin, 600mcg Hydroxocobalamin, 600mcg Adenosylcobalamin)
  • 15mg Riboflavin (as R5P)
  • 10mg Vitamin B6 (as P5P)
  • 5mg Zinc (as Zinc Bisglycinate)
  • 750mg Trimethylglycine (TMG) (as Betaine Anhydrous)
  • 200mg CDP-Choline (Citicoline)
How to Take

Take two (2) capsules daily, or as recommended by your healthcare professional.

The Science

Methylate was designed around nutrients involved in one-carbon metabolism, methylation pathways, and healthy homocysteine metabolism.‡ Folate, B12, B6, and riboflavin support B-vitamin-dependent pathways, while TMG and CDP-choline provide methyl donor support through betaine-related pathways.‡

  • Folate, B12, B6, and homocysteine metabolism
    Review discussing folate, vitamin B12, and vitamin B6 as coenzymes involved in homocysteine metabolism.
    PMID: 9587042
  • B vitamins and one-carbon metabolism
    Review discussing folate, B12, B6, and B2 as coenzymes involved in one-carbon metabolism.
    PMID: 11813080
  • TMG/betaine and methyl donor support
    Review discussing betaine as a methyl donor involved in homocysteine remethylation through betaine-homocysteine methyltransferase pathways.
    PMCID: PMC8224793
  • Choline, betaine, and homocysteine metabolism
    Review discussing choline conversion to betaine and its role as a substrate in the betaine-homocysteine methyltransferase reaction.
    PMID: 20446114
  • Riboflavin and MTHFR-related methylation pathways
    Human study evaluating riboflavin’s role in homocysteine metabolism in individuals with the MTHFR 677TT genotype.
    PMID: 16380544

View Certificate of Analysis (COA) →

3rd-Party Tested
Physician Formulated
Gluten-Free
Made in USA

Manufactured and quality-tested in the USA with globally sourced ingredients.

FAQs

Please read our FAQs page to find out more.

When should I take Methylate?

Take 2 capsules daily, or as recommended by your healthcare professional. Most people take Methylate in the morning with food — methylated B vitamins are activating for some people and can interfere with sleep if taken late in the day. Each bottle contains 180 capsules, a 90-day supply at the recommended dose.

How long does Methylate take to work?

Methylated B vitamins are absorbed and used by the body immediately — they don't need a conversion step. That said, most people take Methylate consistently for 4–8 weeks before noticing a difference in how they feel day to day. Individual experience varies with diet, sleep, stress, and overall nutritional status.

Why methylated B vitamins instead of standard forms?

Methylate uses the bioactive, body-ready forms of each B vitamin: methylfolate (5-MTHF) instead of folic acid, methylcobalamin instead of cyanocobalamin, pyridoxal-5-phosphate (P5P) instead of pyridoxine, and riboflavin-5-phosphate (R5P) instead of standard B2. These methylated forms bypass the enzymatic conversion step that some people — particularly those with MTHFR gene variants — can't perform efficiently. The result is direct utilization, without depending on the body to activate the inactive precursor.

Does Methylate contain folic acid?

No. Methylate uses methylfolate (5-MTHF) — the active form of folate the body actually uses — not folic acid. Folic acid is a synthetic precursor that must go through multiple enzymatic conversion steps before the body can use it; methylfolate skips those steps. We don't use folic acid in any Marek Supplements formula.

Who shouldn't take Methylate?

Methylate is intended for adults 18 and older. If you are pregnant, nursing, taking any medications, or have a medical condition — including kidney disease — consult your physician before use. Some people sensitive to methyl donors (TMG, methylfolate, methylcobalamin) may experience overstimulation, particularly when starting a methylated B-complex for the first time; if you notice agitation, anxiety, or sleep disruption, discontinue use and consult a healthcare provider. Keep out of reach of children.

Can I stack Methylate with other Marek Supplements?

Yes. Methylate is designed to integrate with the rest of the modular Marek Supplements lineup. It pairs naturally with Mag² + Boron (magnesium is a cofactor for methylation reactions) and Daily D3/K2 (vitamin D supports related cellular processes).

How long does shipping take?

We ship fast — orders go out within 1 business day. From there:

  • Standard (3–7 business days): Free on orders over $99 within contiguous U.S.
  • Expedited (2–3 business days): Available at checkout

You'll receive tracking info by email as soon as your order ships.

Do you ship internationally?

We currently ship within the U.S. only.
International shipping is coming — sign up for our newsletter and we'll let you know when it's available.

Are your supplements third-party tested?

Every single batch of Marek Supplements is manufactured in a cGMP-compliant, NSF/ANSI 455-2 certified U.S. facility, with globally sourced ingredients tested by two ISO-accredited laboratories for identity, potency, heavy metals, microbial contaminants, and allergens. Because what's on the label should be what's in the bottle — and nothing else.

Do you offer subscriptions?

Absolutely. Choose Subscribe & Save at checkout and we'll ship every 90 days — you'll save 10% on every order, and you can pause, skip, or cancel whenever you like.

Are your supplements non-GMO and gluten-free?

Yes. All Marek Supplements are non-GMO and gluten-free (verified by third-party lab testing), with no artificial dyes or preservatives.

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MAREK SUPPLEMENTS

Daily schedule

Capsule Powder

Morning

Before eating

FASTED

Glutamine

$30/90-days

5g in water

Breakfast

With food containing fat

WITH MEAL

Methylate

$70/90-days

2 capsules

Thyroid Support

$75/90-days

1 capsule

P5P+

$70/90-days

1 capsule

Daily D3/K2

$50/90-days

1 capsule

Berberine5 (dose 1/2)

$75/90-days

1 capsule · with carbs

Lunch

Midday, with food

WITH MEAL

Liver Support

$125/90-days

2 capsules

Berberine5 (dose 2/2)

$75/90-days

1 capsule · with carbs

Anytime

Flexible timing

FLEXIBLE

Calm

$75/90-days

1 capsule · non-sedating, day or night

Creatine

$30/90-days

5g in water · consistency > timing

Before Bed

30-60 min before sleep

WIND DOWN

Mag2+ Boron

$70/90-days

4 capsules

Glycine

$30/90-days

5g in water or chamomile tea

Berberine5: Take each capsule with your two largest carb-containing meals of the day.

These statements have not been evaluated by the Food and Drug Administration. Dosing guidance is educational only and not a substitute for medical advice. Consult your healthcare provider before starting any new protocol.